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- Severe cardiovascular disorders such as unstable angina
- Any problems of the heart
- Stroke
- Severe cardiac failure
- High blood pressure
- Loss of vision in one due non-arteritic anterior ischaemic optic neuropathy (NAION),
- Renal impairment (Kidney problems)
- Severe hepatic impairment ( liver problems)
- Hypotension (blood pressure < 90/50 mmHg)
- Recent history of stroke or myocardial infarction
- Hereditary degenerative retinal disorders
- Genetic disorders of retinal phosphodiesterases
